Rhoderick Milne blogged about AV and Exchange, this topic is a critical one during the design process of any solution and the exchange admin should be aware of the gotchas of this process. I wrote about this topic for Exchange Server 2007 here at MSExchange.org (http://www.msexchange.org/articles-tutorials/exchange-server-2007/security-message-hygiene/configuring-file-level-antivirus-software.html)
Scanning Exchange databases with file system antivirus is a recipe for disaster. This really should not come as a surprise for admins running Exchange services within the enterprise, since this has been the field requirement for a long time. The documentation provided by Microsoft is very clear in what exclusions are required for file system antivirus and Exchange to coexist. For reference the relevant articles are:
If this is so well documented, then what could possibly go wrong? Plenty….
Read more at source: http://blogs.technet.com/b/rmilne/archive/2014/02/04/exchange-and-antivirus-exclusions-a-critical-conversation.aspx