Consider that you have deployed Forefront TMG 2010 along with Exchange Edge and Forefront Protection for Exchange 2010 (FPE), and you have also enabled the E-Mail Policy feature in TMG.
In addition, you have configured from the TMG Management console some Content Filtering settings related to Exchange Edge.
The problem is that you notice that these settings are ignored. For instance:
You have defined a quarantine mailbox address based on spam confidence level (SCL) rating. Problem is that messages rated with a greater or equal SCL will never be sent to this mailbox.
The problem doesn't happen for non Content Filtering settings like Allow/Block lists, Sender ID, etc …