MDT 2010 supports the use of DFS for replicating deployment shares between sites. But what about replication the MDT database, which is typically either an SQL Server Express database or a full SQL Server database, between sites? Is this possible? And is it recommended?
Because the SQL query traffic for an MDT deployment is typically very small, replicating the SQL Server database between sites is not necessary. Instead, you should maintain a single instance of the MDT database at corporate headquarters and simply replicate the deployment share content out to your branch office sites.
If you want a more robust multi-site deployment platform however, consider using MDT 2010 together with System Center Configuration Manager 2007 R2 which provides additional capabilities not found in MDT alone.