Customers frequently ask Exchange Customer Support Services (CSS) engineers how Exchange Server organizations can be managed using multiple Web sites for Exchange Server-related virtual directories. This is often used for segmentation purposes or for access by certain applications, apart from Web users.
Microsoft Hosted Messaging and Collaboration (HMC) solutions are available for customers with a need to manage multiple Exchange "organizations" from the same platform. However, many customers simply wish to use existing hardware and software without using an HMC solution.
Read more at source: http://msexchangeteam.com/archive/2008/01/07/447828.aspx
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