Two great tools you cannot miss!
Buster Sandbox Analyzer is a tool that has been designed to analyze the behaviour of processes and the changes made to system and then evaluate if they are malware suspicious. The changes made to system can be of several types: file system changes, registry changes and port changes.
On the other, Sandboxie runs your programs in an isolated space which prevents them from making permanent changes to other programs and data in your computer.
Read more and download both tools from here - http://bsa.isoftware.nl/