If you have configured HTTPS Inspection on TMG you may not be able to access some sites such as Twitter and Dropbox.
In this scenario clients will get a blank page and in the TMG logs you will see the error 0x8009000a.
Find out why and how to fix it here:
http://blogs.technet.com/b/isablog/archive/2014/05/28/tmg-https-inspection-is-failing-if-the-target-web-site-is-using-a-cng-certificate.aspx